1-Methylpiperazine → HCID 14054138, compound

HRID 2057909Notes

Reaction equation

HRID 2057909 reaction equation
Cl[CH2:2][CH2:3][C:4]([N:6]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[C:10](=[O:17])[NH:9][C:8]2[CH:18]=[CH:19][CH:20]=[N:21][C:7]1=2)=[O:5].[CH3:22][N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>>[CH3:22][N:23]1[CH2:28][CH2:27][N:26]([CH2:2][CH2:3][C:4]([N:6]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[C:10](=[O:17])[NH:9][C:8]3[CH:18]=[CH:19][CH:20]=[N:21][C:7]2=3)=[O:5])[CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 1381057111-(3-chloropropionyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

Product 1

HCID 14054138HCID 14054138, compoundYield 51%

Procedure

Using the procedure of Example 2, 11-(3-chloropropionyl)-5,11-dihydro-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-one and 1-methyl-piperazine were reacted to obtain a 51% yield of 5,11-dihydro-11-[3-(4-methyl-1-piperazinyl)-propionyl]-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-one which melted at 232°-233° C. after crystallization from an ethyl acetate-ethanol mixture. The dihydrochloride thereof melted at 235° C. after crystallization from ethanol.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-c72b73484c1345fcb53ae600766a0388
Source dataset
uspto-grants-1980_07
Patent number
US04213985

Reaction notes

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