HCID 1073878, compound → HCID 20329389, compound

HRID 2057911Notes

Reaction equation

HRID 2057911 reaction equation
Cl[CH2:2][CH2:3][C:4]([N:6]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[C:10](=[O:17])[NH:9][C:8]2[CH:18]=[CH:19][CH:20]=[N:21][C:7]1=2)=[O:5].[CH3:22][C:23](=[CH2:31])[CH2:24][N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>>[CH3:31][C:23](=[CH2:22])[CH2:24][N:25]1[CH2:30][CH2:29][N:28]([CH2:2][CH2:3][C:4]([N:6]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[C:10](=[O:17])[NH:9][C:8]3[CH:18]=[CH:19][CH:20]=[N:21][C:7]2=3)=[O:5])[CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 1073878HCID 1073878, compoundHCID 1381057111-(3-chloropropionyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

Product 1

HCID 20329389HCID 20329389, compoundYield 45%

Procedure

Using the procedure of Example 2, 11-(3-chloropropionyl)-5,11-dihydro-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-one was reacted with 1-(2-methyl-allyl)-piperazine to obtain a 45% yield of 5,11-dihydro-11-{3-[4-(2-methyl-allyl)-1-piperazinyl]-propionyl}-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-one melting at 210°-211° C. after crystallization from ethanol.

Sources & evidence

ORD record
ord-fbefbd71dd8e429b8f6c1b764342a555
Source dataset
uspto-grants-1980_07
Patent number
US04213985

Reaction notes

Loading…