11-(3-chloropropionyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one → HCID 86737102, compound

HRID 2057912Notes

Reaction equation

HRID 2057912 reaction equation
[Cl:1][CH2:2][CH2:3][C:4]([N:6]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[C:10](=[O:17])[NH:9][C:8]2[CH:18]=[CH:19][CH:20]=[N:21][C:7]1=2)=[O:5].[CH2:22]([N:42]1[CH2:47][CH2:46][NH:45][CH2:44][CH2:43]1)/[CH:23]=[C:24](/[CH2:26][CH2:27][CH2:28][C@@H:29]([CH2:31][CH2:32][CH2:33][C@@H:34]([CH2:36][CH2:37][CH2:38][CH:39]([CH3:41])[CH3:40])[CH3:35])[CH3:30])\[CH3:25]>>[ClH:1].[ClH:1].[CH2:22]([N:42]1[CH2:43][CH2:44][N:45]([CH2:2][CH2:3][C:4]([N:6]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[C:10](=[O:17])[NH:9][C:8]3[CH:18]=[CH:19][CH:20]=[N:21][C:7]2=3)=[O:5])[CH2:46][CH2:47]1)/[CH:23]=[C:24](/[CH2:26][CH2:27][CH2:28][C@@H:29]([CH2:31][CH2:32][CH2:33][C@@H:34]([CH2:36][CH2:37][CH2:38][CH:39]([CH3:40])[CH3:41])[CH3:35])[CH3:30])\[CH3:25]

Participants

3

Reactant 2

HCID 1381057111-(3-chloropropionyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-oneHCID 86737104HCID 86737104, compound

Product 1

HCID 86737102HCID 86737102, compoundYield 62%

Procedure

Using the procedure of Example 7, 11-(3-chloropropionyl)-5,11-dihydro-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-one was reacted with 1-phytyl-piperazine to obtain a 62% yield of 5,11-dihydro-11-[3-(4-phytyl-1-piperazinyl)-propionyl]-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-one dihydrochloride which melted at 204°-210° C. (with decomposition) after crystallization from ethanol.

Sources & evidence

ORD record
ord-0de5e6c4d17c4b8897d1012d95cc1c87
Source dataset
uspto-grants-1980_07
Patent number
US04213985

Reaction notes

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