1-Methylpiperazine → 5,11-dihydro-11-[6-(4-methyl-1-piperazinyl)-caproyl]-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-one

HRID 2057914Notes

Reaction equation

HRID 2057914 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([N:9]1[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[C:13](=[O:20])[NH:12][C:11]2[CH:21]=[CH:22][CH:23]=[N:24][C:10]1=2)=[O:8].[CH3:25][N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>>[CH3:25][N:26]1[CH2:31][CH2:30][N:29]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([N:9]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[C:13](=[O:20])[NH:12][C:11]3[CH:21]=[CH:22][CH:23]=[N:24][C:10]2=3)=[O:8])[CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 1592430211-(6-chlorocaproyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

Product 1

HCID 159243045,11-dihydro-11-[6-(4-methyl-1-piperazinyl)-caproyl]-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-oneYield 36%

Procedure

Using the procedure of Example 9, the product of Step A was reacted with 1-methyl-piperazine to obtain a 36% yield of 5,11-dihydro-11-[6-(4-methyl-1-piperazinyl)-caproyl]-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-one melting at 179°-181° C. after crystallization from ethyl acetate.

Sources & evidence

ORD record
ord-72b22703fc8740f2b6bb72ecd1a5de91
Source dataset
uspto-grants-1980_07
Patent number
US04213985

Reaction notes

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