Hydrogen Bromide → HCID 20329310, compound

HRID 2057916Notes

Reaction equation

HRID 2057916 reaction equation
COC1C=CC(C[O:8][CH2:9][C:10]2[N:14]3[C:15]4[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][C:16]=4[N:17]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[C:18](=[O:20])[CH2:19][C:13]3=[N:12][N:11]=2)=CC=1.Br.[OH-].[Na+]>C(O)(=O)C>[OH:8][CH2:9][C:10]1[N:14]2[C:15]3[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][C:16]=3[N:17]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:18](=[O:20])[CH2:19][C:13]2=[N:12][N:11]=1

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 14798Sodium HydroxideHCID 20329357HCID 20329357, compound

Product 1

HCID 20329310HCID 20329310, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

3.1 g of 1-[(p-methoxybenzyloxy)-methyl]-8-chloro-6-phenyl-4H-s-triazolo[4,3-a][1,5]benzodiazepin-5-one in 30 ml acetic acid, at 25°, is stirred with 24 ml 48% aqueous hydrobromic acid for 20 minutes. The reaction is neutralized with 30% aqueous sodium hydroxide and extracted with chloroform. The organic phase is separated, washed with water, dried and the solvent evaporated to give the title compound.

Workup

  1. extractionextracted with chloroform
  2. customThe organic phase is separated
  3. washwashed with water
  4. customdried
  5. customthe solvent evaporated

Sources & evidence

ORD record
ord-9e0bbb06e4914c9a922ab842a9ae59e0
Source dataset
uspto-grants-1980_07
Patent number
US04213982

Reaction notes

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