HCID 20329348, compound → HCID 20329341, compound

HRID 2057928Notes

Reaction equation

HRID 2057928 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[N:19]3[C:20]4[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][C:21]=4[N:22]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[C:23](=[O:25])[CH2:24][C:18]3=[N:17][N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>FC(F)(F)C(O)=O>[N:11]1([CH2:14][C:15]2[N:19]3[C:20]4[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][C:21]=4[N:22]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[C:23](=[O:25])[CH2:24][C:18]3=[N:17][N:16]=2)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

3

Reactant 1

HCID 20329348HCID 20329348, compound

Product 1

HCID 20329341HCID 20329341, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

2 g. of 1-[4-(t-butoxycarbonyl)-piperazinomethyl]-8-chloro-6-phenyl-4H-s-triazolo[4,3-a][1,5]benzodiazepin-5-one in 50 ml of trifluoroacetic acid is stirred for 2 hours. The reaction mixture is evaporated and the residue partitioned between methylene chloride and aqueous sodium bicarbonate. The organic phase is washed with water, dried and evaporated to give the title compound.

Workup

  1. customThe reaction mixture is evaporated
  2. customthe residue partitioned between methylene chloride and aqueous sodium bicarbonate
  3. washThe organic phase is washed with water
  4. customdried
  5. customevaporated

Sources & evidence

ORD record
ord-3302fe3bf59d43ca9346b270f0292913
Source dataset
uspto-grants-1980_07
Patent number
US04213982

Reaction notes

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