Triethylamine → HCID 12928950, compound

HRID 2057938Notes

Reaction equation

HRID 2057938 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.C(N(CC)CC)C.[Br:19][C:20]1[CH:25]=[CH:24][C:23]([S:26][CH2:27][CH2:28][NH2:29])=[CH:22][CH:21]=1>C1C=CC=CC=1>[Br:19][C:20]1[CH:21]=[CH:22][C:23]([S:26][CH2:27][CH2:28][NH:29][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]=[CH:4][N:3]=2)=[CH:24][CH:25]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 788644-ChloroquinazolineHCID 42061569326-62-1

Product 1

HCID 12928950HCID 12928950, compoundYield 55.5%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To a solution of 2.5 g (0.015 mol) of 4-chloroquinazoline in 50 ml of benzene were added 1.5 g (0.015 mol) of triethylamine and 3.5 g (0.015 mol) of 2-(p-bromophenylthio) ethylamine, and the mixture was heated, with stirring, at 70°~80° C. for 3 hours. After completion of the reaction, the benzene was evaporated under reduced pressure and the resulting crystals were washed with water, collected by filtration and recrystallized from ethanol, giving 3.0 g of 4-[2-(4-bromophenylthio)ethyl]aminoquinazoline in the form of colorless granules.

Workup

  1. temperaturethe mixture was heated
  2. customAfter completion of the reaction
  3. customthe benzene was evaporated under reduced pressure
  4. washthe resulting crystals were washed with water
  5. filtrationcollected by filtration
  6. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-04b779dd4939486e8543825458f399f5
Source dataset
uspto-grants-1980_07
Patent number
US04213987

Reaction notes

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