Nitric Acid → HCID 70506468, compound

HRID 2057946Notes

Reaction equation

HRID 2057946 reaction equation
[N+:1]([O-:4])([OH:3])=[O:2].[Cl:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[S:12][CH:13]([CH2:20][CH2:21][C:22]1[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][CH:23]=1)[CH2:14][N:15]1[CH:19]=[CH:18][N:17]=[CH:16]1>CCOCC>[N+:1]([O-:4])([OH:3])=[O:2].[Cl:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[S:12][CH:13]([CH2:20][CH2:21][C:22]1[CH:23]=[CH:24][C:25]([O:28][CH3:29])=[CH:26][CH:27]=1)[CH2:14][N:15]1[CH:19]=[CH:18][N:17]=[CH:16]1

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 20329506HCID 20329506, compound

Product 1

HCID 70506468HCID 70506468, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Nitric acid (70%; d=1.42) was added dropwise to a stirred solution of 2.0 g of 1-[2-(2-chlorophenylthio)-4-(4-methoxyphenyl)-n-butyl]imidazole in 30 ml of anhydrous ether until precipitation was complete. The product was filtered off, washed with ether, air dried, and recrystallized from ethyl acetate to yield 1-[2-(2-chlorophenylthio)-4-(4-methoxyphenyl)n-butyl]imidazole nitrate, mp 131.5°-133.5° C.

Workup

  1. filtrationThe product was filtered off
  2. washwashed with ether, air
  3. customdried
  4. customrecrystallized from ethyl acetate

Sources & evidence

ORD record
ord-f338cb54a3704ff4bede40784995ebd8
Source dataset
uspto-grants-1980_07
Patent number
US04213991

Reaction notes

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