HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → Ethyl 5-(4-(1-(hydroxyimino)ethyl)phenyl)-2-benzofurancarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Ethyl 5-(4-acetylphenyl)benzofuran-2-carboxylate | HCID 20329647 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Ethyl 5-(4-(1-(hydroxyimino)ethyl)phenyl)-2-benzofurancarboxylate | HCID 73676876 | — |
Reaction Steps
A mixture of 6.2 g of 10A, 100 ml of ethanol and 200 ml of tetrahydrofuran was heated to 60°-70° C. A solution of 1.53 g of hydroxylamine hydrochloride and 1.16 g of sodium carbonate in 20 ml of water was added. The mixture was heated for 3 hours at 60°-70° C. The resulting solid was collected, washed with water, then ethanol, and extracted with methylene chloride. The solvent was evaporated from the extract under reduced pressure to give ethyl 5-(4-(1-(hydroxyimino)ethyl)phenyl)-2-benzofurancarboxylate (12A), mp: 220°-222° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04213998 |
| Source dataset | uspto-grants-1980_07 |
| ORD ID | ord-f7065bee2b854ba8ab9de5e1ee5e20c7 |
| Source note | uspto-grants-1980_07 |