反应详情

A mixture of 6.2 g of 10A, 100 ml of ethanol and 200 ml of tetrahydrofuran was heated to 60°-70° C. A solution of 1.53 g of hydroxylamine hydrochloride and 1.16 g of sodium carbonate in 20 ml of water was added. The mixture was heated for 3 hours at 60°-70° C. The resulting solid was collected, washed with water, then ethanol, and extracted with methylene chloride. The solvent was evaporated from the extract under reduced pressure to give ethyl 5-(4-(1-(hydroxyimino)ethyl)phenyl)-2-benzofurancarboxylate (12A), mp: 220°-222° C.

1. temperaturewas heated to 60°-70° C
2. temperatureThe mixture was heated for 3 hours at 60°-70° C
3. customThe resulting solid was collected
4. washwashed with water
5. extractionethanol, and extracted with methylene chloride
6. customThe solvent was evaporated from the
7. extractionextract under reduced pressure