Sodium Carbonate → HCID 70588073, compound

HRID 2057983Notes

Reaction equation

HRID 2057983 reaction equation
[Cl:1][CH2:2][C:3]([N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[C:9](=[O:16])[NH:8][C:7]2[CH:17]=[CH:18][CH:19]=[N:20][C:6]1=2)=[O:4].C(=O)([O-])[O-].[Na+].[Na+].[CH2:27]([N:37]1[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]1)/[CH:28]=[C:29](\[CH2:31][CH2:32][CH:33]=[C:34]([CH3:36])[CH3:35])/[CH3:30]>C(O)C>[ClH:1].[ClH:1].[CH2:27]([N:37]1[CH2:38][CH2:39][N:40]([CH2:2][C:3]([N:5]2[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[C:9](=[O:16])[NH:8][C:7]3[CH:17]=[CH:18][CH:19]=[N:20][C:6]2=3)=[O:4])[CH2:41][CH2:42]1)/[CH:28]=[C:29](\[CH2:31][CH2:32][CH:33]=[C:34]([CH3:35])[CH3:36])/[CH3:30]

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 12005311-(Chloroacetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-oneHCID 70588103HCID 70588103, compound

Product 1

HCID 70588073HCID 70588073, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5,11-Dihydro-11-[(4-neryl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride was prepared from 5.8 gm of 11-chloroacetyl-5,11-dihydro-6H-pyrido-[2,3-b][1,4]benzodiazepin-6-one, 2.4 gm of sodium carbonate and 5.3 gm of 1-neryl-piperazine in 100 ml of absolute ethanol in analogy to Example 1. The obtained raw product was purified on a silica gel column and converted into the dihydrochloride in absolute ethanol with concentrated hydrochloric acid. After recrystallization from absolute ethanol: M.p.: 188°-191° C.

Workup

  1. customThe obtained raw product
  2. customwas purified on a silica gel column
  3. customAfter recrystallization from absolute ethanol

Sources & evidence

ORD record
ord-ab9496ab6f6a439b8e43ac28b34bc21d
Source dataset
uspto-grants-1980_07
Patent number
US04213984

Reaction notes

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