Sodium Carbonate → HCID 70588073, compound

Participants

Reaction Steps

5,11-Dihydro-11-[(4-neryl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride was prepared from 5.8 gm of 11-chloroacetyl-5,11-dihydro-6H-pyrido-[2,3-b][1,4]benzodiazepin-6-one, 2.4 gm of sodium carbonate and 5.3 gm of 1-neryl-piperazine in 100 ml of absolute ethanol in analogy to Example 1. The obtained raw product was purified on a silica gel column and converted into the dihydrochloride in absolute ethanol with concentrated hydrochloric acid. After recrystallization from absolute ethanol: M.p.: 188°-191° C.

Provenance & Evidence