Triethylamine → HCID 20329367, compound

Participants

Reaction Steps

5.8 gm of 11-chloroacetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one, 3 ml of triethylamine and 4.2 gm of 1-(α-methyl benzyl)-piperazine (R1 = ##STR10## were stirred in 40 ml of dioxane for 2 hours at 80° C. The dark solution was then evaporated in vacuo, and the residue was taken up in chloroform/water and shaken. The organic phase was then clarified with activated charcoal, dried with sodium sulfate and evaporated in vacuo. The residue was recrystallized from a mixture of ethyl acetate and cyclohexane.

Provenance & Evidence