Triethylamine → HCID 20329367, compound

HRID 2057984Notes

Reaction equation

HRID 2057984 reaction equation
Cl[CH2:2][C:3]([N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[C:9](=[O:16])[NH:8][C:7]2[CH:17]=[CH:18][CH:19]=[N:20][C:6]1=2)=[O:4].C(N(CC)CC)C.[CH3:28][CH:29]([N:36]1[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]1)[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>O1CCOCC1>[CH3:28][CH:29]([N:36]1[CH2:41][CH2:40][N:39]([CH2:2][C:3]([N:5]2[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[C:9](=[O:16])[NH:8][C:7]3[CH:17]=[CH:18][CH:19]=[N:20][C:6]2=3)=[O:4])[CH2:38][CH2:37]1)[C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 12005311-(Chloroacetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-oneHCID 27371341-(1-Phenylethyl)piperazine

Product 1

HCID 20329367HCID 20329367, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

5.8 gm of 11-chloroacetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one, 3 ml of triethylamine and 4.2 gm of 1-(α-methyl benzyl)-piperazine (R1 = ##STR10## were stirred in 40 ml of dioxane for 2 hours at 80° C. The dark solution was then evaporated in vacuo, and the residue was taken up in chloroform/water and shaken. The organic phase was then clarified with activated charcoal, dried with sodium sulfate and evaporated in vacuo. The residue was recrystallized from a mixture of ethyl acetate and cyclohexane.

Workup

  1. customThe dark solution was then evaporated in vacuo
  2. dry with materialdried with sodium sulfate
  3. customevaporated in vacuo
  4. customThe residue was recrystallized from a mixture of ethyl acetate and cyclohexane

Sources & evidence

ORD record
ord-32b606927d2347168734050c44eae83e
Source dataset
uspto-grants-1980_07
Patent number
US04213984

Reaction notes

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