Sodium Carbonate → 5,11-Dihydro-11-{[4-(2-morpholino-ethyl)-1-piperazinyl]acetyl}-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

HRID 2057985Notes

Reaction equation

HRID 2057985 reaction equation
Cl[CH2:2][C:3]([N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[C:9](=[O:16])[NH:8][C:7]2[CH:17]=[CH:18][CH:19]=[N:20][C:6]1=2)=[O:4].C(=O)([O-])[O-].[Na+].[Na+].[O:27]1[CH2:32][CH2:31][N:30]([CH2:33][CH2:34][N:35]2[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]2)[CH2:29][CH2:28]1>C(O)C>[O:27]1[CH2:28][CH2:29][N:30]([CH2:33][CH2:34][N:35]2[CH2:36][CH2:37][N:38]([CH2:2][C:3]([N:5]3[C:11]4[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=4[C:9](=[O:16])[NH:8][C:7]4[CH:17]=[CH:18][CH:19]=[N:20][C:6]3=4)=[O:4])[CH2:39][CH2:40]2)[CH2:31][CH2:32]1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 12005311-(Chloroacetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-oneHCID 27346404-(2-Piperazin-1-yl-ethyl)-morpholine

Product 1

HCID 203293695,11-Dihydro-11-{[4-(2-morpholino-ethyl)-1-piperazinyl]acetyl}-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5,11-Dihydro-11-{[4-(2-morpholino-ethyl)-1-piperazinyl]acetyl}-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one was prepared from 8.62 gm of 11-chloroacetyl-5,11-dihydro-6H-pyrido-[2,3-b][1,4]benzodiazepin-6-one, 3.5 gm of sodium carbonate and 6.1 gm of 1-(2-morpholino-ethyl)piperazine in 100 ml of absolute ethanol in analogy to Example 1.

Sources & evidence

ORD record
ord-fa75c7b82e794f3bb5046314180ad88a
Source dataset
uspto-grants-1980_07
Patent number
US04213984

Reaction notes

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