HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 5,11-Dihydro-11-{[4-(2-morpholino-ethyl)-1-piperazinyl]acetyl}-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 11-(Chloroacetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one | HCID 120053 | — |
| Reactant | 4-(2-Piperazin-1-yl-ethyl)-morpholine | HCID 2734640 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5,11-Dihydro-11-{[4-(2-morpholino-ethyl)-1-piperazinyl]acetyl}-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 20329369 | — |
Reaction Steps
5,11-Dihydro-11-{[4-(2-morpholino-ethyl)-1-piperazinyl]acetyl}-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one was prepared from 8.62 gm of 11-chloroacetyl-5,11-dihydro-6H-pyrido-[2,3-b][1,4]benzodiazepin-6-one, 3.5 gm of sodium carbonate and 6.1 gm of 1-(2-morpholino-ethyl)piperazine in 100 ml of absolute ethanol in analogy to Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04213984 |
| Source dataset | uspto-grants-1980_07 |
| ORD ID | ord-fa75c7b82e794f3bb5046314180ad88a |
| Source note | uspto-grants-1980_07 |