Sodium Carbonate → 6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-((4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)acetyl)-5-methyl-

HRID 2057988Notes

Reaction equation

HRID 2057988 reaction equation
Cl[CH2:2][C:3]([N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[C:9](=[O:16])[N:8]([CH3:17])[C:7]2[CH:18]=[CH:19][CH:20]=[N:21][C:6]1=2)=[O:4].C(=O)([O-])[O-].[Na+].[Na+].[CH2:28]1[O:43][C:42]2[CH:41]=[CH:40][C:32]([CH2:33][N:34]3[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]3)=[CH:31][C:30]=2[O:29]1>C(O)C>[CH3:17][N:8]1[C:9](=[O:16])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[N:5]([C:3](=[O:4])[CH2:2][N:37]2[CH2:38][CH2:39][N:34]([CH2:33][C:32]3[CH:40]=[CH:41][C:42]4[O:43][CH2:28][O:29][C:30]=4[CH:31]=3)[CH2:35][CH2:36]2)[C:6]2[N:21]=[CH:20][CH:19]=[CH:18][C:7]1=2

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 944261-PiperonylpiperazineHCID 2032937011-(2-Chloroacetyl)-5,11-dihydro-5-methyl-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

Product 1

HCID 30532206H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-((4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)acetyl)-5-methyl-

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

10.5 gm of 11-chloroacetyl-5,11-dihydro-5-methyl-6H-pyrido[2,3-b]-[1,4]benzodiazepine-6-one, 3.8 gm of sodium carbonate and 8 gm of 1-[(3,4-methylenedioxy)benzyl]-piperazine were reacted in 200 ml of absolute ethanol and worked up in analogy to Example 1.

Sources & evidence

ORD record
ord-b35f5fbf835540988478dcd690f9f8ff
Source dataset
uspto-grants-1980_07
Patent number
US04213984

Reaction notes

Loading…