Sodium Carbonate → HCID 3053221, compound

Participants

Reaction Steps

5.05 gm of 5,11-dihydro-11-[(1-piperazinyl)acetyl]-6H-pyrido-[2,3-b][1,4]benzodiazepin-6-one, 1.6 gm of sodium carbonate and 3.7 gm of cinnamyl bromide were refluxed in 80 ml of n-propanol for 3.5 hours. After evaporation, the residue was dissolved in chloroform/water. The organic phase was dried with sodium sulfate, the chloroform was distilled off, and the residue was purified on a silica gel column. After recrystallization from ethyl acetate.

Provenance & Evidence