Sodium Carbonate → HCID 3053221, compound

HRID 2057989Notes

Reaction equation

HRID 2057989 reaction equation
[N:1]1([CH2:7][C:8]([N:10]2[C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=3[C:14](=[O:21])[NH:13][C:12]3[CH:22]=[CH:23][CH:24]=[N:25][C:11]2=3)=[O:9])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.C(=O)([O-])[O-].[Na+].[Na+].[CH2:32](Br)[CH:33]=[CH:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1>C(O)CC>[CH2:32]([N:4]1[CH2:5][CH2:6][N:1]([CH2:7][C:8]([N:10]2[C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=3[C:14](=[O:21])[NH:13][C:12]3[CH:22]=[CH:23][CH:24]=[N:25][C:11]2=3)=[O:9])[CH2:2][CH2:3]1)[CH:33]=[CH:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 98116BromomethylstyreneHCID 567540HCID 567540, compound

Product 1

HCID 3053221HCID 3053221, compound

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent

Procedure

5.05 gm of 5,11-dihydro-11-[(1-piperazinyl)acetyl]-6H-pyrido-[2,3-b][1,4]benzodiazepin-6-one, 1.6 gm of sodium carbonate and 3.7 gm of cinnamyl bromide were refluxed in 80 ml of n-propanol for 3.5 hours. After evaporation, the residue was dissolved in chloroform/water. The organic phase was dried with sodium sulfate, the chloroform was distilled off, and the residue was purified on a silica gel column. After recrystallization from ethyl acetate.

Workup

  1. customAfter evaporation
  2. dissolutionthe residue was dissolved in chloroform/water
  3. dry with materialThe organic phase was dried with sodium sulfate
  4. distillationthe chloroform was distilled off
  5. customthe residue was purified on a silica gel column
  6. customAfter recrystallization from ethyl acetate

Sources & evidence

ORD record
ord-6d203198fafc4d9eba139288e4d4d49f
Source dataset
uspto-grants-1980_07
Patent number
US04213984

Reaction notes

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