HCID 20329788, compound → HCID 20329773, compound

HRID 2058049Notes

Reaction equation

HRID 2058049 reaction equation
[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([CH2:8][CH2:9][CH2:10][CH:11]2[C:14]([O:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=2)=[O:15])=[CH:6][CH:5]=1)([O-])=O>C(O)(=O)C.[C].[Pd]>[NH2:1][C:4]1[CH:13]=[C:12]2[C:7]([CH2:8][CH2:9][CH2:10][CH:11]2[C:14]([O:16][C:17]2[CH:18]=[CH:19][C:20]([O:23][CH3:24])=[CH:21][CH:22]=2)=[O:15])=[CH:6][CH:5]=1

Participants

4

Reactant 1

HCID 20329788HCID 20329788, compound

Product 1

HCID 20329773HCID 20329773, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 176Acetic AcidSolvent

Procedure

A 0.8-g portion of the p-methoxyphenyl 7-nitro-1,2,3,4-tetrahydro-1-naphthoate obtained above was catalytically reduced with 5% palladium-carbon in acetic acid. After removal of the catalyst by filtration, the acetic acid was removed by distillation under reduced pressure to obtain p-methoxyphenyl 7-amino-1,2,3,4-tetrahydro-1-naphthoate, which was then dissolved in diethyl ether, and dry gaseous hydrogen chloride was introduced into the resulting solution to obtain 520 mg of p-methoxyphenyl 7-amino-1,2,3,4-tetrahydro-1-naphthoate hydrochloride, m.p. 155°-156° C.

Workup

  1. customAfter removal of the catalyst
  2. filtrationby filtration
  3. customthe acetic acid was removed by distillation under reduced pressure

Sources & evidence

ORD record
ord-9c0fbc5cdd6d40fd8e79654674880f7c
Source dataset
uspto-grants-1980_07
Patent number
US04214093

Reaction notes

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