反应详情

A mixture of 500 mg of 4-(4-chloroanilinomethyl)phenol, 632 mg of ethyl 2-bromo-2-methylpropionate, 7.5 ml of methyl isobutyl ketone and 448 mg of potassium carbonate is refluxed under heating for 6 hours. The insolubles are filtered off from the reaction mixture, and the filtrate is washed with water, dried and concentrated. The residue (730 mg) is purified by column chromatography, using 22 g of silica gel and chloroform as a developer to give 410 mg of ethyl 2-[4-(4-chloroanilinomethyl)phenoxy]-2-methylpropionate, mp 58° to 60° C.

1. temperatureis refluxed
2. temperatureunder heating for 6 hours
3. filtrationThe insolubles are filtered off from the reaction mixture
4. washthe filtrate is washed with water
5. customdried
6. concentrationconcentrated
7. customThe residue (730 mg) is purified by column chromatography