Sodium Hydroxide → HCID 54716191, compound

HRID 2058191Notes

Reaction equation

HRID 2058191 reaction equation
C(OC([C:6]1[C:7](=[O:20])[N:8]([CH2:18][CH3:19])[C:9]2[C:14]([C:15]=1[OH:16])=[CH:13][CH:12]=[C:11]([CH3:17])[N:10]=2)=O)C.[OH-].[Na+]>C(O)(=O)C>[CH2:18]([N:8]1[C:9]2[C:14](=[CH:13][CH:12]=[C:11]([CH3:17])[N:10]=2)[C:15]([OH:16])=[CH:6][C:7]1=[O:20])[CH3:19]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 54737589HCID 54737589, compound

Product 1

HCID 54716191HCID 54716191, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A stirred mixture of 0.5 g. of 1-ethyl-1,2-dihydro-4-hydroxy-7-methyl-2-oxo-1,8-naphthyridine-3-carboxylic acid ethyl ester was heated under reflux for 5 hours in 20 ml. of a 20% sodium hydroxide solution was cooled and was acidified with glacial acetic acid. The precipitate which formed was collected, air dried and was recrystallized from ethanol to give 0.2 g. of the title compound, m.p. 320°-3° C. dec.

Workup

  1. additionA stirred mixture of 0.5 g
  2. temperatureunder reflux for 5 hours in 20 ml
  3. customThe precipitate which formed
  4. customwas collected
  5. customair dried
  6. customwas recrystallized from ethanol
  7. customto give 0.2 g

Sources & evidence

ORD record
ord-ff4c463fe4f7499793ef9e77ba185fa2
Source dataset
uspto-grants-1980_07
Patent number
US04215123

Reaction notes

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