反应详情

5.5 g of 2-(p-benzoylphenoxy)ethylamine and 13 g of chloroformic acid ethyl ester are dissolved in 200 ml of acetone. 19.3 g of potassium carbonate are added to the solution and the mixture is heated under reflux with stirring for 30 hours. The mixture is then filtered and the crystals are washed with acetone. The filtrate is evaporated in vacuo. The residue is dissolved in ethyl acetate. The organic phase is washed with water, dried over sodium sulfate and evaporated in vacuo. The residue is dissolved in ether and crystallized by the addition of cyclohexane to yield 3.8 g (61%) of 2-(p-benzoylphenoxy)ethylcarbamic acid ethyl ester, m.p.--84°-86° C.

1. temperaturethe mixture is heated
2. temperatureunder reflux
3. filtrationThe mixture is then filtered
4. washthe crystals are washed with acetone
5. customThe filtrate is evaporated in vacuo
6. dissolutionThe residue is dissolved in ethyl acetate
7. washThe organic phase is washed with water
8. dry with materialdried over sodium sulfate
9. customevaporated in vacuo
10. dissolutionThe residue is dissolved in ether
11. customcrystallized by the addition of cyclohexane