Chlorotrimethylsilane → HCID 23349506, compound

HRID 2058292Notes

Reaction equation

HRID 2058292 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[CH:5][C:6]2[N:12]([CH3:13])[C:11](=[O:14])[CH2:10][N:9]=[C:8]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[C:7]=2[CH:21]=1.[CH3:24][Si:25]([CH3:28])([CH3:27])Cl>>[F:23][C:2]([F:1])([F:22])[C:3]1[CH:4]=[CH:5][C:6]2[N:12]([CH3:13])[C:11]([O:14][Si:25]([CH3:28])([CH3:27])[CH3:24])=[CH:10][N:9]=[C:8]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[C:7]=2[CH:21]=1

Participants

3

Reactant 2

HCID 6397ChlorotrimethylsilaneHCID 23349511HCID 23349511, compound

Product 1

HCID 23349506HCID 23349506, compound

Procedure

Following the general procedure of Part A, 2.4 g of 7-trifluoromethyl-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one was reacted with trimethylchlorosilane. The filtrate was evaporated, the residue was dissolved in CFCl3 and the CFCl3 was removed by evaporation to give 7-trifluoromethyl-1-methyl-5-phenyl-2-trimethylsiloxy-1H-1,4-benzodiazepin which was again dissolved in CFCl3 and reacted with trifluoromethyl hypofluorite to give 7-trifluoromethyl-3-fluoro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one whose measured mass spectrum was m/c 336.0859; Calculated for C17H12ON2F4 : 336.0885.

Workup

  1. customThe filtrate was evaporated
  2. dissolutionthe residue was dissolved in CFCl3
  3. customthe CFCl3 was removed by evaporation

Sources & evidence

ORD record
ord-dcdd730112874f8e872c9b750fd5555c
Source dataset
uspto-grants-1980_07
Patent number
US04215044

Reaction notes

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