Chlorotrimethylsilane → HCID 23349506, compound

Participants

Reaction Steps

Following the general procedure of Part A, 2.4 g of 7-trifluoromethyl-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one was reacted with trimethylchlorosilane. The filtrate was evaporated, the residue was dissolved in CFCl3 and the CFCl3 was removed by evaporation to give 7-trifluoromethyl-1-methyl-5-phenyl-2-trimethylsiloxy-1H-1,4-benzodiazepin which was again dissolved in CFCl3 and reacted with trifluoromethyl hypofluorite to give 7-trifluoromethyl-3-fluoro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one whose measured mass spectrum was m/c 336.0859; Calculated for C17H12ON2F4 : 336.0885.

Provenance & Evidence