2,4-Dichlorobenzyl chloride → 1-[3-(3,4-Dichloroanilino)-2-(2,4-dichlorobenzyloxy)propyl]-imidazole

HRID 2058322Notes

Reaction equation

HRID 2058322 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][C:17]=1[Cl:18])[NH:5][CH2:6][CH:7]([OH:14])[CH2:8][N:9]1[CH:13]=[CH:12][N:11]=[CH:10]1.[Cl:19][C:20]1[CH:27]=[C:26]([Cl:28])[CH:25]=[CH:24][C:21]=1[CH2:22]Cl>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][C:17]=1[Cl:18])[NH:5][CH2:6][CH:7]([O:14][CH2:22][C:21]1[CH:24]=[CH:25][C:26]([Cl:28])=[CH:27][C:20]=1[Cl:19])[CH2:8][N:9]1[CH:13]=[CH:12][N:11]=[CH:10]1

Participants

3

Reactant 2

HCID 72122,4-Dichlorobenzyl chlorideHCID 233502001-[3-(3,4-Dichloroanilino)-2-hydroxypropyl]imidazole

Product 1

HCID 233501941-[3-(3,4-Dichloroanilino)-2-(2,4-dichlorobenzyloxy)propyl]-imidazole

Procedure

Reaction of 1-[3-(3,4-dichloroanilino)-2-hydroxypropyl]-imidazole with 2,4-dichlorobenzyl chloride yields 1-[3-(3,4-dichloroanilino)-2-(2,4-dichlorobenzyloxy)propyl]-imidazole. The base, purified by recrystallization from isopropanol, melts at 116°-117° C.; the methanesulfonate salt melts at 141°-143° C.

Sources & evidence

ORD record
ord-15d20438b9b74395849488b666f5b136
Source dataset
uspto-grants-1980_07
Patent number
US04215220

Reaction notes

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