HRID2058399

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID31348

Citrate

C6H5O7-3

结构：C1CCC(NC2CCCCC2)CC1.COc1cc(OC)cc(C(C)(C)OC(=O)N[C@@H](Cc2ccc(OC(C)(C)C)cc2)C(=O)N[C@@H](CCC(N)=O)C(=O)O)c1

HCID131711837

未命名化合物

PRODUCTS

生成物

结构：COc1cc(OC)cc(C(C)(C)OC(=O)N[C@@H](Cc2ccc(OC(C)(C)C)cc2)C(=O)N[C@@H](CCC(N)=O)C(=O)O)c1

HCID131711836

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

2.9 g (3.77 mmols) of Ddz-Tyr(But)-Gln-OH-DCHA were partitioned between ethyl acetate and citrate buffer (pH 3). The ethyl acetate phase was washed neutral with water, dried over Na2SO4 and concentrated. An amorphous product was obtained.

WORKUP

后处理

washThe ethyl acetate phase was washed neutral with water
dry with materialdried over Na2SO4
concentrationconcentrated
customAn amorphous product was obtained

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ab192210aa864f4497a7316f29b441ea
来源数据集: uspto-grants-1980_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04215037
来源说明: uspto-grants-1980_07

反应 SMILES

[NH:1]([C:27]([O:29][C:30]([C:33]1[CH:42]=[C:39]([O:40][CH3:41])[CH:38]=[C:35]([O:36][CH3:37])[CH:34]=1)([CH3:32])[CH3:31])=[O:28])[C@H:2]([C:15]([NH:17][C@H:18]([C:24]([OH:26])=[O:25])[CH2:19][CH2:20][C:21](=[O:23])[NH2:22])=[O:16])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[CH:6][CH:5]=1.C1CCC(NC2CCCCC2)CC1.C([O-])(=O)CC(CC([O-])=O)(C([O-])=O)O>C(OCC)(=O)C>[NH:1]([C:27]([O:29][C:30]([C:33]1[CH:42]=[C:39]([O:40][CH3:41])[CH:38]=[C:35]([O:36][CH3:37])[CH:34]=1)([CH3:31])[CH3:32])=[O:28])[C@H:2]([C:15]([NH:17][C@H:18]([C:24]([OH:26])=[O:25])[CH2:19][CH2:20][C:21](=[O:23])[NH2:22])=[O:16])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[CH:6][CH:5]=1