HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → H-Thr(But)-Ser(But)-OH.HCl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Z-Thr(But)-Ser(But)OH | HCID 129820266 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | H-Thr(But)-Ser(But)-OH.HCl | HCID 131711820 | — |
Reaction Steps
25 g (55.24 mmols) of Z-Thr(But)-Ser(But)OH were dissolved in 200 ml of methanol and catalytically hydrogenated (pH 4.5) on an autotitrator with the addition of methanolic HCl. When hydrogenation was complete, the Pd/BaSO4 catalyst was removed by suction filtration, the filtrate was concentrated and dried in a high vacuum. Yield 21.1 g of an amorphous product (19.60 g 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04215037 |
| Source dataset | uspto-grants-1980_07 |
| ORD ID | ord-22d1c3f0e2a44d858df4fb1791ff1447 |
| Source note | uspto-grants-1980_07 |