Hydrochloric Acid → H-Thr(But)-Ser(But)-OH.HCl

HRID 2058401Notes

Reaction equation

HRID 2058401 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:10]([NH:12][C@H:13]([C:20]([OH:22])=[O:21])[CH2:14][O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:11])[C@@H:3]([CH3:9])[O:4][C:5]([CH3:8])([CH3:7])[CH3:6].[ClH:33]>CO>[NH2:1][C@H:2]([C:10]([NH:12][C@H:13]([C:20]([OH:22])=[O:21])[CH2:14][O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:11])[C@@H:3]([CH3:9])[O:4][C:5]([CH3:8])([CH3:7])[CH3:6].[ClH:33]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 129820266Z-Thr(But)-Ser(But)OH

Product 1

HCID 131711820H-Thr(But)-Ser(But)-OH.HCl

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

25 g (55.24 mmols) of Z-Thr(But)-Ser(But)OH were dissolved in 200 ml of methanol and catalytically hydrogenated (pH 4.5) on an autotitrator with the addition of methanolic HCl. When hydrogenation was complete, the Pd/BaSO4 catalyst was removed by suction filtration, the filtrate was concentrated and dried in a high vacuum. Yield 21.1 g of an amorphous product (19.60 g 100%).

Workup

  1. customthe Pd/BaSO4 catalyst was removed by suction filtration
  2. concentrationthe filtrate was concentrated
  3. customdried in a high vacuum

Sources & evidence

ORD record
ord-22d1c3f0e2a44d858df4fb1791ff1447
Source dataset
uspto-grants-1980_07
Patent number
US04215037

Reaction notes

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