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HRID2058416

反应详情

EQUATION

反应方程式

HRID 2058416 的结构方程式

REACTANTS

反应物

4
结构：[Na+].[OH-]
HCID14798

Sodium Hydroxide

HNaO

结构：CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccc(O)cc3)C(=O)N2[C@H]1C(=O)O
HCID33613

Amoxicillin

C16H19N3O5S

结构：CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccc(O)cc3)C(=O)N2[C@H]1C(=O)O.O.O.O
HCID62883

Amoxicillin hydrate (1:3)

C16H25N3O8S

结构：OC1CCCO1
HCID93002

Oxolan-2-ol

C4H8O2

PRODUCTS

生成物

1
结构：CC1(C)SC2C(NC(=O)C(NC3CCCO3)c3ccc(O)cc3)C(=O)N2C1C(=O)[O-].[Na+]
HCID77872850

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

CONDITIONS

反应条件

温度
25 °C

PROCEDURE

实验过程

To a stirred suspension of 6.28 g (0.015) mol) of amoxicillin trihydrate in 150 ml of distilled water was added in one portion 15 ml of 1 N aqueous sodium hydroxide solution. The amoxicillin quickly dissolved and after two minutes 2.25 g (0.025 mol) of tetrahydro-2-furanol was added. After stirring at 25° C. for two minutes the solution was quickly frozen by means of a dry ice-acetone bath and then lyophilized for 22 hr. The resulting product {2S-[2α, 5α, 6β(S*)]}-6-{[2-tetrahydrofuranylamino(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt (6.55 g) was obtained as a white powder.

WORKUP

后处理

  1. additionwas added
  2. temperaturewas quickly frozen by means of a dry ice-acetone bath
  3. waitlyophilized for 22 hr