反应详情

A mixture of 3-[3-[(1-piperidinyl)methyl]phenoxy]propanamine (4.97 g.) and 1,1-bis-(methylthio)-2-nitroethene (6.61 g.) in tetrahydrofuran (100 ml.) was heated under reflux for 19 hours. A solution of oxalic acid (6.25%) in tetrahydrofuran (4 ml.) was added, the suspension filtered and to the filtrate was added a solution of oxalic acid (6.25%) in tetrahydrofuran (36 ml.). The solid which separated on trituration was filtered, washed with tetrahydrofuran and dried to give the title compound (7.36 g.), m.p. 71°-75°.

1. temperaturewas heated
2. temperatureunder reflux for 19 hours
3. filtrationthe suspension filtered and to the filtrate
4. additionwas added a solution of oxalic acid (6.25%) in tetrahydrofuran (36 ml.)
5. customThe solid which separated on trituration
6. filtrationwas filtered
7. washwashed with tetrahydrofuran
8. customdried