Sodium Bicarbonate → 1-Methylthio-1-[3-[3-(piperidinomethyl)phenoxy]propyl]amino-2-nitroethene

HRID 2058425Notes

Reaction equation

HRID 2058425 reaction equation
C(O)(=O)C(O)=O.[N+:7]([CH:10]=[C:11]([S:30][CH3:31])[NH:12][CH2:13][CH2:14][CH2:15][O:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([CH2:23][N:24]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)[CH:18]=1)([O-:9])=[O:8].C(=O)(O)[O-].[Na+]>O>[N+:7]([CH:10]=[C:11]([S:30][CH3:31])[NH:12][CH2:13][CH2:14][CH2:15][O:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([CH2:23][N:24]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)[CH:18]=1)([O-:9])=[O:8]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 705472272-Nitro-N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-1-(methylthio)etheneamine oxalate

Product 1

HCID 678820931-Methylthio-1-[3-[3-(piperidinomethyl)phenoxy]propyl]amino-2-nitroetheneYield 90%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 2-nitro-N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-1-(methylthio)ethenamine oxalate (0.9 g.) in water (20 ml.) was added sodium bicabonate (3 g.). The suspension was extracted with ethyl acetate (2×20 ml.), the extracts dried (Na2CO3) and evaporated in vacuo to give the title compound (0.65 g.).

Workup

  1. extractionThe suspension was extracted with ethyl acetate (2×20 ml.)
  2. dry with materialthe extracts dried (Na2CO3)
  3. customevaporated in vacuo

Sources & evidence

ORD record
ord-0f813dcd25eb4e0b8dfdf29734403e0b
Source dataset
uspto-grants-1982_03
Patent number
US04317819

Reaction notes

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