Imidazole → HCID 20550244, compound

HRID 2058445Notes

Reaction equation

HRID 2058445 reaction equation
Br[CH2:2][CH:3]1[CH2:8][CH2:7][CH:6]([CH3:9])[CH2:5][CH2:4]1.[NH:10]1[CH:14]=[CH:13][N:12]=[CH:11]1.CC(C)([O-])C.[K+]>C(O)CCC>[CH3:9][CH:6]1[CH2:7][CH2:8][CH:3]([CH2:2][N:10]2[CH:14]=[CH:13][N:12]=[CH:11]2)[CH2:4][CH2:5]1

Participants

5

Reactant 3

HCID 795ImidazoleHCID 134603641-(Bromomethyl)-4-methylcyclohexaneHCID 23665647Potassium tert-butoxide

Product 1

HCID 20550244HCID 20550244, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

1-Bromomethyl-4-methylcyclohexane (3.1 g, 0.0162 mol) was added dropwise to a stirred, boiling solution of imidazole (1.12 g, 0.0165 mol) and potassium t-butoxide (1.85 g, 0.0165 mol) in dry n-butanol, under dry nitrogen. After the addition, the reaction mixture was stirred and heated under reflux for 10 h.

Workup

  1. additionAfter the addition
  2. temperatureheated
  3. temperatureunder reflux for 10 h.

Sources & evidence

ORD record
ord-bfaef8f7ff4b434dbd9c733d1c1916f0
Source dataset
uspto-grants-1982_03
Patent number
US04317830

Reaction notes

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