Dichloromethane → N-[4-(6-{2-[(Piperidin-4-ylmethyl)-amino]-4-trifluoromethyl-phenyl}-pyrimidin-4-yloxy)-benzothiazol-2-yl]-acetamide

HRID 205852Notes

Reaction equation

HRID 205852 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:14][NH:15][c:16]2[c:17](-[c:26]3[n:27][cH:28][n:29][c:30]([O:32][c:33]4[cH:34][cH:35][cH:36][c:37]5[c:38]4[n:39][c:40]([NH:42][C:43]([CH3:44])=[O:45])[s:41]5)[cH:31]3)[cH:18][cH:19][c:20]([C:22]([F:23])([F:24])[F:25])[cH:21]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:53][CH2:54][Cl:55].[OH:46][C:47]([C:48]([F:49])([F:50])[F:51])=[O:52]>>[NH:8]1[CH2:9][CH2:10][CH:11]([CH2:14][NH:15][c:16]2[c:17](-[c:26]3[n:27][cH:28][n:29][c:30]([O:32][c:33]4[cH:34][cH:35][cH:36][c:37]5[c:38]4[n:39][c:40]([NH:42][C:43]([CH3:44])=[O:45])[s:41]5)[cH:31]3)[cH:18][cH:19][c:20]([C:22]([F:23])([F:24])[F:25])[cH:21]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 218651314-({2-[6-(2-Acetylamino-benzothiazol-4-yloxy)-pyrimidin-4-yl]-5-trifluoromethyl-phenylamino}-methyl)-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 21865312N-[4-(6-{2-[(Piperidin-4-ylmethyl)-amino]-4-trifluoromethyl-phenyl}-pyrimidin-4-yloxy)-benzothiazol-2-yl]-acetamide

Sources & evidence

ORD record
ord-c3396aa630f041c5b6889f611699854d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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