Hydrochloric Acid → 2,3-Dichloro-5-(trichloromethyl)pyridine

HRID 2058560Notes

Reaction equation

HRID 2058560 reaction equation
Br[C:2]1[C:3]([Cl:9])=[N:4][CH:5]=[C:6](C)[CH:7]=1.[ClH:10].ClCl.[C:13]([Cl:17])(Cl)([Cl:15])[Cl:14]>>[Cl:9][C:3]1[C:2]([Cl:10])=[CH:7][C:6]([C:13]([Cl:17])([Cl:15])[Cl:14])=[CH:5][N:4]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 5943Carbon TetrachlorideHCID 24526ChlorineHCID 2854373-Bromo-2-chloro-5-methylpyridine

Product 1

HCID 946472,3-Dichloro-5-(trichloromethyl)pyridine

Procedure

The product from (b) (64 g) in dry carbon tetrachloride (650 ml) was treated with dry hydrogen chloride. The precipitate was broken up and the suspension heated under reflux while dry chlorine was bubbled into the mixture, with illumination from an ultra-violet light source. After 41/2 hours, the mixture was cooled, filtered, and the filtrate evaporated to give the required 2,3-dichloro-5-trichloromethylpyridine. The mass spectrum was consistent with the structure assigned to this compound.

Workup

  1. temperaturethe suspension heated
  2. customwas bubbled into the mixture, with illumination from an ultra-violet light source
  3. temperatureAfter 41/2 hours, the mixture was cooled
  4. filtrationfiltered
  5. customthe filtrate evaporated

Sources & evidence

ORD record
ord-6257f8d3fce04d5caa64ebda471996ab
Source dataset
uspto-grants-1982_03
Patent number
US04317913

Reaction notes

Loading…