HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 4-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)acetyl]-1,3-dimethyl-1,4,9,10-tetrahydropyrazolo[4,3-b][1,5]benzodiazepin-10-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | Triethylethylenediamine | HCID 66040 | — |
| Reactant | 2-Ethylaminoethyldimethylamine | HCID 67162 | — |
| Reactant | 1,2-Ethanediamine, N1,N1,N2-trimethyl- | HCID 67338 | — |
| Reactant | 1-Benzylpiperazine | HCID 75994 | — |
| Reactant | 1-Ethylpiperazine | HCID 79196 | — |
| Reactant | 1-Methylhomopiperazine | HCID 228349 | — |
| Reactant | 1,3-Dimethylpiperazine | HCID 13152035 | — |
| Reactant | 4-Chloroacetyl-1,3-dimethyl-1,4,9,10-tetrahydropyrazolo[4,3-b][1,5]benzodiazepin-10-one | HCID 20549878 | — |
| Product | 4-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)acetyl]-1,3-dimethyl-1,4,9,10-tetrahydropyrazolo[4,3-b][1,5]benzodiazepin-10-one | HCID 20549983 | — |
Reaction Steps
are obtained analogously by reacting 4-chloroacetyl-1,3-dimethyl-1,4,9,10-tetrahydropyrazolo[4,3-b][1,5]benzodiazepin-10-one with corresponding amounts (instead of with N-methylpiperazine) of morpholine, N-benzylpiperazine, N-ethylpiperazine, 1,3-dimethylpiperazine, N,N,N'-trimethylethylenediamine, N,N,N'-triethylethylenediamine, N'-ethyl-N,N-dimethylethylenediamine and hexahydro-1-methyl-1H-1,4-diazepine, respectively.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04317823 |
| Source dataset | uspto-grants-1982_03 |
| ORD ID | ord-32780066e3304ef486ae50ea4d87f802 |
| Source note | uspto-grants-1982_03 |