Morpholine → HCID 20549983, compound

HRID 2058599Notes

Reaction equation

HRID 2058599 reaction equation
Cl[CH2:2][C:3]([N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[NH:9][C:8](=[O:16])[C:7]2[N:17]([CH3:21])[N:18]=[C:19]([CH3:20])[C:6]1=2)=[O:4].[CH3:22][N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1.N1CCOC[CH2:30]1.C(N1CCNCC1)C1C=CC=CC=1.C(N1CCNCC1)C.CN1CCNC(C)C1.CN(C)CCNC.C(N(CC)CCNCC)C.C(NCCN(C)C)C.CN1CCCNCC1>>[CH3:30][N:23]1[CH2:22][CH2:24][CH2:25][N:26]([CH2:2][C:3]([N:5]2[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[NH:9][C:8](=[O:16])[C:7]3[N:17]([CH3:21])[N:18]=[C:19]([CH3:20])[C:6]2=3)=[O:4])[CH2:27][CH2:28]1

Participants

11

Reactant 10

HCID 8083MorpholineHCID 531671-MethylpiperazineHCID 66040TriethylethylenediamineHCID 671622-EthylaminoethyldimethylamineHCID 673381,2-Ethanediamine, N1,N1,N2-trimethyl-HCID 759941-BenzylpiperazineHCID 791961-EthylpiperazineHCID 2283491-MethylhomopiperazineHCID 131520351,3-DimethylpiperazineHCID 20549878HCID 20549878, compound

Product 1

HCID 20549983HCID 20549983, compound

Procedure

are obtained analogously by reacting 4-chloroacetyl-1,3-dimethyl-1,4,9,10-tetrahydropyrazolo[4,3-b][1,5]benzodiazepin-10-one with corresponding amounts (instead of with N-methylpiperazine) of morpholine, N-benzylpiperazine, N-ethylpiperazine, 1,3-dimethylpiperazine, N,N,N'-trimethylethylenediamine, N,N,N'-triethylethylenediamine, N'-ethyl-N,N-dimethylethylenediamine and hexahydro-1-methyl-1H-1,4-diazepine, respectively.

Workup

  1. customare obtained analogously

Sources & evidence

ORD record
ord-32780066e3304ef486ae50ea4d87f802
Source dataset
uspto-grants-1982_03
Patent number
US04317823

Reaction notes

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