反应详情

2.0 g of 4-chloroacetyl-1,3-dimethyl-1,4,9,10-tetrahydropyrazolo[4,3-b][1,5]benzodiazepin-10-one, 0.55 g of pyrrolidine, 0.85 g of ground sodium carbonate and 15 ml of absolute ethanol are heated at the boil for 2 hours; the hot solution is then filtered and concentrated in vacuo. The thus-obtained residue is dissolved in ethylene chloride, and the resulting organic solution is washed at pH 7 with water and concentrated to yield 2.05 g of 1,3-dimethyl-4-(pyrrolidinoacetyl)-1,4,9,10-tetrahydropyrazolo[4,3-b][1,5]benzodiazepin-10-one, mp 114° to 116° C. (from toluene).

1. filtrationthe hot solution is then filtered
2. concentrationconcentrated in vacuo
3. dissolutionThe thus-obtained residue is dissolved in ethylene chloride
4. washthe resulting organic solution is washed at pH 7 with water
5. concentrationconcentrated