2-Amino-2-methyl-1-propanol → HCID 86737466, compound

HRID 2058647Notes

Reaction equation

HRID 2058647 reaction equation
[CH3:1][C:2]1([CH3:13])[CH2:8][CH2:7][CH2:6][CH:5]([CH3:9])[CH:4]([C:10](Cl)=[O:11])[CH2:3]1.[NH2:14]C(C)(C)CO>C(Cl)Cl>[CH3:1][C:2]1([CH3:13])[CH2:8][CH2:7][CH2:6][CH:5]([CH3:9])[CH:4]([C:10]([NH2:14])=[O:11])[CH2:3]1

Participants

4

Reactant 2

HCID 118072-Amino-2-methyl-1-propanolHCID 20549179HCID 20549179, compound

Product 1

HCID 86737466HCID 86737466, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

3,3,7-Trimethylcycloheptanecarbonyl chloride, prepared from the product of Part A by the method of Example 26 Part B, (0.5 g. 0.0025 mole) in 10 ml methylene dichloride was added to a stirred solution of 2-amino-2,2-dimethylethanol (0.5 g) in 50 ml methylene dichloride. After 3 hours the solution was washed with 2N HC1, then with NaHCO3 solution and then dried (MgSO4). Removal of the solvent left an oil which was distilled to yield N-1', 1'-dimethyl-2'-hydroxyethyl)-3,3,7-trimethylcycloheptanecarboxamide, bp. 135°/0.015 mm.

Workup

  1. washAfter 3 hours the solution was washed with 2N HC1
  2. dry with materialwith NaHCO3 solution and then dried (MgSO4)
  3. customRemoval of the solvent
  4. waitleft an oil which
  5. distillationwas distilled

Sources & evidence

ORD record
ord-be2e157738324f71b2babd00646c889b
Source dataset
uspto-grants-1982_03
Patent number
US04318900

Reaction notes

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