Guanidine → HCID 178496513, compound

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Reaction Steps

The compound of Example 1b was prepared by stirring 4.0 g (0.016 mols) 2-(2,6-dichlorophenyl)-2-methoxy-acetic acid methyl ester with 0.025 mols guanidine (from 2.4 g guanidine hydrochloride and 0.6 g sodium) in 50 ml ethanol for 2 days at room temperature. After evaporation, the residue is taken up in a water/chloroform mixture, and the chloroform phase is further mixed with ethanolic hydrochloric acid. In this way, the desired hydrochloride salt is obtained. It decomposes at 242 to 243 degrees C.

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