Guanidine → HCID 178496513, compound

HRID 2058649Notes

Reaction equation

HRID 2058649 reaction equation
C[O:2][C:3](=O)[CH:4]([C:7]1[C:12]([Cl:13])=[CH:11][CH:10]=[CH:9][C:8]=1[Cl:14])[O:5][CH3:6].[NH2:16][C:17]([NH2:19])=[NH:18]>C(O)C>[ClH:13].[Cl:14][C:8]1[CH:9]=[CH:10][CH:11]=[C:12]([Cl:13])[C:7]=1[CH:4]([O:5][CH3:6])[C:3]([NH:18][C:17]([NH2:19])=[NH:16])=[O:2]

Participants

4

Reactant 2

HCID 3520GuanidineHCID 53711297HCID 53711297, compound

Product 1

HCID 178496513HCID 178496513, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The compound of Example 1b was prepared by stirring 4.0 g (0.016 mols) 2-(2,6-dichlorophenyl)-2-methoxy-acetic acid methyl ester with 0.025 mols guanidine (from 2.4 g guanidine hydrochloride and 0.6 g sodium) in 50 ml ethanol for 2 days at room temperature. After evaporation, the residue is taken up in a water/chloroform mixture, and the chloroform phase is further mixed with ethanolic hydrochloric acid. In this way, the desired hydrochloride salt is obtained. It decomposes at 242 to 243 degrees C.

Workup

  1. customAfter evaporation
  2. additionthe chloroform phase is further mixed with ethanolic hydrochloric acid

Sources & evidence

ORD record
ord-f17a2e817a1341529ead6c732a93d9d8
Source dataset
uspto-grants-1982_03
Patent number
US04318915

Reaction notes

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