反应详情

A mixture of benzyl 6-(1-hydroxyethyl)-3-toluenesulfonyloxy-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylate (30 mg), 10% palladium on charcoal (30 mg), sodium bicarbonate (6 mg), dioxane (3 ml) and water (1 ml) is hydrogenated at 40 psi for 30 mins. The mixture is filtered to remove the catalyst which is washed with water (3×3 ml) The combined filtrate is extracted with ethylacetate (3×2 ml), concentrated in vacuo to ca. 2 ml, and lyophilized to give sodium 6-(1-hydroxyethyl)-3-toluenesulfonyloxy-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylate.

1. filtrationThe mixture is filtered
2. customto remove the catalyst which
3. washis washed with water (3×3 ml) The combined filtrate
4. extractionis extracted with ethylacetate (3×2 ml)
5. concentrationconcentrated in vacuo to ca. 2 ml