Acetic Acid → 1-(2-Carboxybenzylidene)-2-(benzoxazol-2-yl)-2-methylhydrazine

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Reaction Steps

To a stirred suspension of 1.6 g. of the benzoxazole intermediate product of Example 1 in 50 ml. of glacial acetic acid is added 1.5 g. of 2-carboxybenzaldehyde. After a few minutes the mixture becomes homogeneous, then quickly thickens as a new precipitate forms. Stirring is continued for 16 hours, water is added, and the solid is filtered, washed with water and dried to give 2.5 g. of product, m.p. 253°-5°.

Provenance & Evidence