Benzene → HCID 12906807, compound

HRID 2058787Notes

Reaction equation

HRID 2058787 reaction equation
[CH3:1][C:2]1([CH3:7])[NH:6][CH2:5][CH2:4][S:3]1.C1C=CC=CC=1.[Br:14][CH:15]([Br:19])[C:16](Cl)=[O:17]>C(N(CC)CC)C>[CH3:1][C:2]1([CH3:7])[N:6]([C:16](=[O:17])[CH:15]([Br:19])[Br:14])[CH2:5][CH2:4][S:3]1

Participants

5

Reactant 3

HCID 241BenzeneHCID 79184Dibromoacetyl chlorideHCID 880152,2-Dimethylthiazolidine

Product 1

HCID 12906807HCID 12906807, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

To a mixture of 3.5 g. of 2,2-dimethyl thiazolidine, 50 ml. of benzene and 7.1 g. of dibromoacetyl chloride mixed in an ice bath was added 3.1 g. of triethylamine dropwise with stirring and continued cooling. When reaction was complete, the mixture was poured into watwer and the benzene layer separated, dried over magnesium sulfate and the benzene removed under vacuum. Yield was 8.5 g. of a dark oil.

Workup

  1. additionTo a mixture of 3.5 g
  2. additionwas added 3.1 g
  3. temperaturecontinued cooling
  4. customWhen reaction
  5. additionthe mixture was poured into watwer
  6. customthe benzene layer separated
  7. dry with materialdried over magnesium sulfate
  8. customthe benzene removed under vacuum

Sources & evidence

ORD record
ord-9fdcb91d3ecf463ca31c2f273ca8846c
Source dataset
uspto-grants-1982_03
Patent number
US04319031

Reaction notes

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