Acetic Acid → HCID 70548340, compound

HRID 2058798Notes

Reaction equation

HRID 2058798 reaction equation
[Na].O[CH:3]=[CH:4][C:5]#[N:6].C(O)(=O)C.[NH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1.N1CCOCC1.C(O)(=O)C>C(#N)C>[NH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH:12]1[CH:3]=[CH:4][C:5]#[N:6]

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 8083MorpholineHCID 11964105Morpholine, acetateHCID 86738287Sodium 3-hydroxyacrylonitrile

Product 1

HCID 70548340HCID 70548340, compoundYield 75.4%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
65 °C

Procedure

30.3 g (0.25 mol) of sodium-3-hydroxyacrylonitrile (content 75%) is added to a solution of morpholine acetate (prepared from 26.1 g (0.3 mol) of morpholine and 18 g (0.3 mol) of acetic acid) in 200 ml of acetonitrile and is heated for 8 h at 65° C. After working up as in Example 55, 26.0 g (75.4%) of 3-morpholine acrylonitrile was obtained.

Sources & evidence

ORD record
ord-c6eaf038b41046baa922de5942057c08
Source dataset
uspto-grants-1982_03
Patent number
US04319024

Reaction notes

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