Dimethylamine → HCID 20549598, compound

HRID 2058809Notes

Reaction equation

HRID 2058809 reaction equation
BrCCC1C2[C:7](=CC=CC=2)[NH:6][CH:5]=1.[C:13]1(=O)[O:17][CH2:16][CH2:15][CH2:14]1.Br[CH2:20][CH2:21][C:22]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][C:29]=2[Cl:31])[NH:24][CH:23]=1.[C:32]1(=O)OC[CH2:34][CH2:33]1.C(OCC)(=O)CC(C)=O.CNC>>[Cl:31][C:29]1[CH:28]=[CH:27][CH:26]=[C:25]2[C:30]=1[C:22]1[CH2:21][CH2:20][CH2:32][C:33]([CH3:34])([CH:14]([CH2:13][N:6]([CH3:7])[CH3:5])[CH2:15][CH2:16][OH:17])[C:23]=1[NH:24]2

Participants

6

Reactant 5

HCID 674DimethylamineHCID 7302Gamma-ButyrolactoneHCID 769243-(2-Bromoethyl)indoleHCID 20549588HCID 20549588, compoundHCID 20549599HCID 20549599, compound

Product 1

HCID 20549598HCID 20549598, compound

Procedure

By following the procedure of this example and using the appropriate compounds of formulae IV, V and VIII and amine of formula HNR5R6, other compounds of formula I are obtained. For example, by using 3-(2-bromoethyl)-4-chloroindole, ethyl acetoacetate γ-butyrolactone and dimethylamine, 5-chloro-γ-[(dimethylamino)methyl]-1-methyl-1,2,3,4-tetrahydrocarbazole-1-propanol is obtained.

Workup

  1. customare obtained

Sources & evidence

ORD record
ord-678caf3e0bd543cf927bd04c0fc70a79
Source dataset
uspto-grants-1982_03
Patent number
US04319029

Reaction notes

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