Benzylaniline → HCID 13037487, compound

HRID 2058886Notes

Reaction equation

HRID 2058886 reaction equation
[CH2:1]([NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:15][O:16][C:17]1[CH:22]=[C:21]([O:23][CH3:24])[CH:20]=[CH:19][C:18]=1[P:25](Cl)(Cl)=[O:26]>>[CH3:15][O:16][C:17]1[CH:22]=[C:21]([O:23][CH3:24])[CH:20]=[CH:19][C:18]=1[P:25]1(=[O:26])[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[CH2:1][N:8]1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 66028BenzylanilineHCID 20548444HCID 20548444, compound2×

Product 1

HCID 13037487HCID 13037487, compoundYield 66%

Procedure

The procedure of Example 1 was employed utilizing N-benzylaniline and 2,4-dimethoxyphenyl phosphonic dichloride. The reaction of the dilithio compound and the 2,4-dimethoxyphenyl phosphonic dichloride was conducted at -76° C. to yield 1-(2,4-dimethoxyphenyl)-2-phenyl-2,3-dihydro-1H-2,1-benzazaphosphole-1-oxide (7.2 g, 66% yield) as a white solid having a melting point of 173°-175° C. and the following analysis:

Workup

  1. customwas conducted at -76° C.

Sources & evidence

ORD record
ord-4c65926bfefc45829776e43438c2d45b
Source dataset
uspto-grants-1982_03
Patent number
US04319913

Reaction notes

Loading…