反应详情

The procedure of Example 1 was employed utilizing dibenzylamine and isopropyl phosphonic dichloride. The reaction of the dilithio compound and the isopropyl phosphonic dichloride was conducted at -65° C. The crude product produced as a result of the chromatographic separation was distilled at 160° C. and 0.2 mm to yield a colorless oil. The colorless oil was slurried in petroleum ether to yield 1-isopropyl-2-phenylmethyl-2,3-dihydro-1H-2,1-benzazaphosphole-1-oxide (1.15 g, 12% yield) as a colorless solid having a melting point of 145°-147° C. and the following analysis:

1. customwas conducted at -65° C
2. customThe crude product produced as
3. customa result of the chromatographic separation
4. distillationwas distilled at 160° C.
5. custom0.2 mm to yield a colorless oil