Benzylaniline → HCID 13037494, compound

HRID 2058893Notes

Reaction equation

HRID 2058893 reaction equation
[CH2:1]([NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:15][O:16][C:17]1[CH:18]=[C:19]([P:23](Cl)(Cl)=[O:24])[CH:20]=[CH:21][CH:22]=1>>[CH3:15][O:16][C:17]1[CH:18]=[C:19]([P:23]2(=[O:24])[C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[CH2:1][N:8]2[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:20]=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 66028BenzylanilineHCID 12670627HCID 12670627, compound2×

Product 1

HCID 13037494HCID 13037494, compoundYield 27%

Procedure

The procedure of Example 1 was employed utilizing N-benzylaniline and 3-methoxyphenyl phosphonic dichloride. The reaction of the dilithio compound and the 3-methoxyphenyl phosphonic dichloride was conducted at 0° C. to yield 1-(3-methoxyphenyl)-2-phenyl-2,3-dihydro-1H-2,1-benzazaphosphole-1-oxide (2.75 g, 27% yield) as a solid having a melting point of 170°-172° C. and the following analysis:

Workup

  1. customwas conducted at 0° C.

Sources & evidence

ORD record
ord-20a24870317c4040b8e909fd1fafa834
Source dataset
uspto-grants-1982_03
Patent number
US04319913

Reaction notes

Loading…