Benzylaniline → HCID 13037506, compound

HRID 2058906Notes

Reaction equation

HRID 2058906 reaction equation
[CH2:1]([NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:15][C:16]1[CH:21]=[CH:20][C:19]([P:22](Cl)(Cl)=[O:23])=[CH:18][CH:17]=1>>[F:15][C:16]1[CH:21]=[CH:20][C:19]([P:22]2(=[O:23])[C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[CH2:1][N:8]2[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 66028BenzylanilineHCID 12670632(4-Fluorophenyl)phosphonic dichloride

Product 1

HCID 13037506HCID 13037506, compoundYield 30%

Procedure

The procedure of Example 26 was employed utilizing N-benzylaniline and 4-fluorophenyl phosphonic dichloride to yield a pale yellow solid. The yellow solid was recrystallized from ethyl acetate to yield 1-(4-fluorophenyl)-2-phenyl-2,3-dihydro-1H-2,1-benzazaphosphole-1-oxide (5.9 g, 30% yield) as white needles having a melting point of 119°-120° C. and the following analysis:

Workup

  1. customto yield a pale yellow solid
  2. customThe yellow solid was recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-dcc07b202940428cb8ba73153129951c
Source dataset
uspto-grants-1982_03
Patent number
US04319913

Reaction notes

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